LIST-S2 (species specific) predicts the deleteriousness of amino acid mutations in protein sequences. First, it aligns (high Local identity Pair-wise Sequence Alignment, LPSA) the query sequence to all protein sequences in the UniProt Swiss-Prot/TrEMBL database and then it identifies the most relevant homologies based on their local identity to the query sequence around that position. And finally, it estimates the potential deleteriousness of mutations based on Taxonomy distance of species with variations to the query.

Prediction scores are in the range [0 .. 1], where lower scores indicate more benign and higher indicate deleteriousness effect.


Malhis N, Jacobson M, Jones SJM, Gsponer J. LIST-S2: taxonomy based sorting of deleterious missense mutations across species. Nucleic Acids Research (2020) Apr 30. doi:10.1093/nar/gkaa288. PMID: 32352516

Terms & Conditions

This software is distributed on an as is basis, without any kind of warranties. This software is free for all. Appropriate citation when using LIST-S2 in publication of scientific results.

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